Pre-treatment Delta Neutrophil Index as a Predictive Factor in Renal Cell Carcinoma

OBJECTIVE To determine the diagnostic value of pre-treatment delta neutrophil index (DNI) before treatment in patients with renal cell carcinoma (RCC) and to compare this marker other routine inflammation markers, such as neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR). STUDY DESIGN Descriptive study. PLACE AND DURATION OF Department Urology, Kahramanmaras Sutcu Imam University, Turkey, from February 2017 January 2020. METHODOLOGY Data who underwent radical nephrectomy for RCC, were evaluated. For comparison, healthy individuals included study a control group. Demographic data, age, gender, laboratory tests, DNI, NLR, PLR levels groups recorded compared. RESULTS There 73 RCC group 71 NLR significantly higher (p <0.001, each). DNI advanced stage (T3-T4) high grade (G3-G4). In univariate logistic regression analysis hemoglobin (p=0.023), (p<0.001), lymphocyte (p=0.009), platelet (p<0.001) identified predictors RCC. multivariate analysis, (p<0.001, each) found be Cut-off values 0.45% 1.80 130.09 PLR. CONCLUSION is new inflammatory marker, which complete blood count parameters; does not require any additional calculation, unlike It can used prediction Key Words: Renal carcinoma, Delta index, Neutrophil-lymphocyte ratio, Platelet-lymphocyte ratio.